# Douglas A. Mata, MD, MPH ![img_8978_180x140_2.jpg](/sites/g/files/omnuum4676/files/styles/hwp_1_1__720x720_scale/public/dmata/files/img_8978_180x140_2.jpg?itok=7CSSQ3Iy) Douglas A. Mata, MD, MPH, is an anatomic and clinical pathologist who trained as a resident physician at the Brigham and Women’s Hospital, as a clinical fellow at Harvard Medical School, and as molecular genetic pathology fellow at Memorial Sloan Kettering Cancer Center. He received his bachelor’s degree in biochemistry from Rice University, his medical degree from Baylor College of Medicine, and his master's degree in public health from the University of Cambridge. He was also a Fulbright Scholar at the European campus of the M.D. Anderson Cancer Center in Madrid, Spain. Dr. Mata currently serves as a non-resident tutor in pre-medicine at Dunster House, Harvard College. His letters, editorials, and original research have appeared in *New England Journal of Medicine*, *Journal of the American Medical Association*, *Journal of Surgical Oncology*, *Lancet Psychiatry*, and *Proceedings of the National Academy of Sciences*, and his work has been featured in *Newsweek*, *New York Times*, *Time Magazine*, *U.S. News & World Report*, and the *Washington Post*. Follow him on Twitter @[DouglasMataMD](https://twitter.com/DouglasMataMD). ## Recent Publications Download 6 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=719846&content_filter%5B1%5D=719841&content_filter%5B2%5D=719836&content_filter%5B3%5D=719881&content_filter%5B4%5D=719856&content_filter%5B5%5D=719871&&format=ris) ### 2024 Kerr D, Cloutier J, Margolis M, Mata D, Rodrigues Simoes N, Faquin W, Dias-Santagata D, Chopra S, Charville G, Wangsiricharoen S, et al. [GLI1-Altered Mesenchymal Tumors With ACTB or PTCH1 Fusion: A Molecular and Clinicopathologic Analysis](/publications/gli1-altered-mesenchymal-tumors-actb-or-ptch1-fusion-molecular-and). Mod Pathol. 2024;37(2):100386. doi:10.1016/j.modpat.2023.100386 Kerr D, Cloutier J, Margolis M, Mata D, Rodrigues Simoes N, Faquin W, Dias-Santagata D, Chopra S, Charville G, Wangsiricharoen S, et al. [GLI1-Altered Mesenchymal Tumors With ACTB or PTCH1 Fusion: A Molecular and Clinicopathologic Analysis](/publications/gli1-altered-mesenchymal-tumors-actb-or-ptch1-fusion-molecular-and). Mod Pathol. 2024;37(2):100386. doi:10.1016/j.modpat.2023.100386 - add\_circle\_outline do\_not\_disturb\_on Abstract Mesenchymal tumors with GLI1 fusions or amplifications have recently emerged as a distinctive group of neoplasms. The terms GLI1-altered mesenchymal tumor or GLI1-altered soft tissue tumor serve as a nosological category, although the exact boundaries... Williams E, Vegas I, El-Senduny F, Zhang J, Mata D, Hiemenz M, Hughes S, Sa B, Kraft G, Gorbatov N, et al. [Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma](/publications/pan-cancer-genomic-analysis-axl-mutations-reveals-novel-recurrent-functionally). Am J Surg Pathol. 2024. doi:10.1097/PAS.0000000000002191 Williams E, Vegas I, El-Senduny F, Zhang J, Mata D, Hiemenz M, Hughes S, Sa B, Kraft G, Gorbatov N, et al. [Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma](/publications/pan-cancer-genomic-analysis-axl-mutations-reveals-novel-recurrent-functionally). Am J Surg Pathol. 2024. doi:10.1097/PAS.0000000000002191 - add\_circle\_outline do\_not\_disturb\_on Abstract Myxofibrosarcoma (MFS) is a common soft tissue sarcoma of the elderly that typically shows low tumor mutational burden, with mutations in TP53 and in genes associated with cell cycle checkpoints (RB1, CDKN2A). Unfortunately, no alterations or markers... Mata D, Lee J, Shanmugam V, Marcus C, Schrock A, Williams E, Ritterhouse L, Hickman R, Janovitz T, Patel N, et al. [Liquid biopsy-based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results](/publications/liquid-biopsy-based-circulating-tumour-ctdna-analysis-spectrum-myeloid-and). Histopathology. 2024. doi:10.1111/his.15168 Mata D, Lee J, Shanmugam V, Marcus C, Schrock A, Williams E, Ritterhouse L, Hickman R, Janovitz T, Patel N, et al. [Liquid biopsy-based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results](/publications/liquid-biopsy-based-circulating-tumour-ctdna-analysis-spectrum-myeloid-and). Histopathology. 2024. doi:10.1111/his.15168 - add\_circle\_outline do\_not\_disturb\_on Abstract AIMS: Liquid biopsy (LBx)-based next-generation sequencing (NGS) of circulating tumour DNA (ctDNA) can facilitate molecular profiling of haematopoietic neoplasms (HNs), particularly when tissue-based NGS is infeasible.METHODS AND RESULTS: We studied HN... ### 2023 Grube V, Narla S, Mata D, Hafeez F. [Comparing Follicular Extension Between Low-Grade and High-Grade Dysplastic Nevi](/publications/comparing-follicular-extension-between-low-grade-and-high-grade-dysplastic-nevi). Am J Dermatopathol. 2023;45(6):423–424. doi:10.1097/DAD.0000000000002438 Grube V, Narla S, Mata D, Hafeez F. [Comparing Follicular Extension Between Low-Grade and High-Grade Dysplastic Nevi](/publications/comparing-follicular-extension-between-low-grade-and-high-grade-dysplastic-nevi). Am J Dermatopathol. 2023;45(6):423–424. doi:10.1097/DAD.0000000000002438 - add\_circle\_outline do\_not\_disturb\_on Abstract Dysplastic nevi are an important subset of melanocytic nevi with atypical clinical, histopathologic, as well as genomic features compared with common acquired nevi. Dysplastic nevi are characterized histologically by both cytologic atypia and... Torre M, Bukhari H, Nithianandam V, Zanella C, Mata D, Feany M. [A Drosophila model relevant to chemotherapy-related cognitive impairment](/publications/drosophila-model-relevant-chemotherapy-related-cognitive-impairment). Sci Rep. 2023;13(1):19290. doi:10.1038/s41598-023-46616-9 Torre M, Bukhari H, Nithianandam V, Zanella C, Mata D, Feany M. [A Drosophila model relevant to chemotherapy-related cognitive impairment](/publications/drosophila-model-relevant-chemotherapy-related-cognitive-impairment). Sci Rep. 2023;13(1):19290. doi:10.1038/s41598-023-46616-9 - add\_circle\_outline do\_not\_disturb\_on Abstract Chemotherapy-related cognitive impairment (CRCI) is a common adverse effect of treatment and is characterized by deficits involving multiple cognitive domains including memory. Despite the significant morbidity of CRCI and the expected increase in cancer... Williams E, Ravindranathan A, Gupta R, Stevers N, Suwala A, Hong C, Kim S, Yuan JB, Wu J, Barreto J, et al. [Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs](/publications/novel-sox10-indel-mutations-drive-schwannomas-through-impaired-transactivation). Neuro Oncol. 2023;25(12):2221–2236. doi:10.1093/neuonc/noad121 Williams E, Ravindranathan A, Gupta R, Stevers N, Suwala A, Hong C, Kim S, Yuan JB, Wu J, Barreto J, et al. [Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs](/publications/novel-sox10-indel-mutations-drive-schwannomas-through-impaired-transactivation). Neuro Oncol. 2023;25(12):2221–2236. doi:10.1093/neuonc/noad121 - add\_circle\_outline do\_not\_disturb\_on Abstract BACKGROUND: Schwannomas are common peripheral nerve sheath tumors that can cause severe morbidity given their stereotypic intracranial and paraspinal locations. Similar to many solid tumors, schwannomas and other nerve sheath tumors are primarily thought... [ More arrow\_circle\_right ](/publications)